ea0013p237 | Neuroendocrinology and behaviour (including pituitary) | SFEBES2007
Sinclair Alexandra
, Onyimba Claire
, Khosla Pamela
, Tomlinson Jeremy
, Burdon Michael
, Murray Philip
, Stewart Paul
, Walker Elizabeth
, Rauz Saaeha
The pre-receptor regulation of glucocorticoids is mediated by 11β-hydroxysteroid dehydrogenases (11β-HSD). The type 1 isoform is primarily responsible for the generation of active cortisol in tissues such as liver and adipose, whereas 11β-HSD2 regulates sodium and ion transport. Recently, we have shown the presence of functional 11β-HSD1 in the ciliary body of the eye where it is important in control of sodium transport, aqueous humour production and intrao...